Serum proteomes of Santa Gertrudis cattle before and after infestation with <i>Rhipicephalus australis</i> ticks

Previous studies have applied genomics and transcriptomics to identify immune genetic markers as key indicator traits for cattle tick susceptibility/resistance; however, results differed between breeds, there is lack of information on the use host proteomics. Serum samples from Santa Gertrudis (naïve phenotyped over 105 days tick-resistant [TR] or tick-susceptible [TS]) were used conduct differential abundance analyses protein profiles. proteins digested into peptides followed by identification quantification using sequential window acquisition all instances theoretical fragment ion mass spectrometry. Before infestation, 28 significantly (adjusted P < 10?5) TR TS. These differences also observed following infestation (TR vs TS) with a further eight differentially abundant in cattle, suggesting possible roles adaptive responses. The intragroup comparisons (TS-0 TS TR-0 TR) showed that elicited quite similar responses both groups but relatively stronger cattle. Many (before after infestation) associated including complement factors, chemotaxis cells acute-phase